SSHD-CM2/S25
The optimal function of CHRM2 and SNAP-25 genes help the body synthesise CHRM2 and SNAP-25 proteins so that people remember better and enjoy an increased IQ. Researchers have discovered that a lack of these two proteins leads to a poor memory and reduced IQ. SSHD-CM2/S25 molecules target CHRM2 and SNAP-25 genes to promote their activities.
What do CHRM2 and SNAP-25 do?
The gene SNAP-25, is located on human chromosome 20. It was discovered by Dr Zhao and colleagues [1]. It is expressed in the brain and encodes synaptosomal-associated protein, 25kDa, a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Reduced SNAP-25 gene activity results in memory loss [2].
The fine structure of the CHRM2 gene was determined by Dr Zhou and colleagues [3]. It encodes a cholinergic receptor, muscarinic 2, that belongs to a larger family of G protein-coupled receptors. In contrast to SNAP-25, CHRM2 is located on chromosome 7.
CHRM2 has been proven to be a key promoter of intelligence [4].
References
- Zhao et al., Cloning and sequence analysis of the human SNAP25 cDNA. Gene, 145: 313, 1994.
- Hou et al., SNAP-25 in hippocampal CA3 region is required for long-term memory formation. Biochem. Biophys. Res. Commun., 347: 955, 2006.
- Zhou et al., Structure of the human M(2) muscarinic acetylcholine receptor gene and its promoter. Gene, 271: 87, 2001.
- Dick et al., Association of CHRM2 with IQ: converging evidence for a gene influencing intelligence. Behav. Genet., 37: 265, 2007.