SSHD-PPG/DF1/KP1

SSHD-PPG/DF1/KP1

A benign tumour of muscular and fibrous tissues, typically developing in the wall of the uterus, is called fibroid. The increased expression of genes, KEAP1, DEFB1 and PPARG play active role to supress such formations. KEAP1 suppresses tumour growth. PPARG has been shown to kill fibroids cells and DEFB1 provides protection against infection. The SSHD- PPG/DF1/KP1 trio molecules target these genes to increase productivity of the gene materials thus control the fibroids.

What do the genes KEAP1, PPARG and DEFB1 do?

KEAP1 is a recently discovered master tumour suppressor gene. Scientists at the M. D. Anderson's Department of Molecular and Cellular Oncology discovered how it works [1]. It suppresses tumour growth by destruction of oncoproteins, proteins that promote tumour growth. It also inhibits tumour invasion or spreading and helps to cut off a tumour’s blood supply so that it its growth is arrested.

Dr. Nam and colleagues [2] have demonstrated that up-regulation of PPARG is helpful in treatment of (leiomyomas) fibroids. They have discovered that stabilisation of the activity of PPARG slows down the growth of fibroids. It also triggers a self-destruct mechanism which causes fibroid cells to kill themselves.

When fibroid cells are killed by the action of PPARG for example, the uterus and uro-genital tract become more prone to infection. The DEFB1 gene produces a small natural anti-bacterial peptide [3] that protects all tissue surfaces from infection. DEFB1 is targeted to help reduce the risk of intra-uterine infection when fibroid cell numbers are diminished.

References